Reality VS Mind

Reality VS Mind refers to a concept brought up a lot by the game about how many of the game's events actually happened and how many are influenced by .'s mind instead. We know that. struggles with retaining a grasp on reality, as her hallucinations are very common and most likely make up most of the enemies in Version 2. It's up to the player to figure out what really happened and what the game shows for the sake of helping the player find more of the deeper lore.

Events that likely aren't real

 * The entirety of E's Mind is a metaphor for E's declining mental state, with Bloodshot E serving as the embodiment of E's dark side. E's Mind isn't a real place, indicated by the name and the fact that E is randomly transported there upon exiting the Kitchen. By extension, it can be assumed that Bloodshot E also isn't real and serves as a part of the metaphor for E's eventual suicide.
 * The Twisted Library may be heavily influenced by .'s mind, evidence for this is that the maze-like layout doesn't make sense as a real location, and once again, you enter Twisted Library randomly when you should've ended up somewhere else. Also like E's Mind, you enter Twisted Library after a bad event takes place, in this case reading E's suicide log, which is also probably not real, and is just . remembering E's suicide, because nobody writes the transcript of a suicide in real life.
 * C's House undergoes a random transformation after seeing Bloodshot D in the hallway, turning into The Spirit House and becoming overrun by vengeful spirits. The reality of Spirit House is unclear, likely a mixture of reality and .'s mind, because all the spirits in the house can be assumed to be real victims.
 * Chapter 4's location is very much akin to E's Mind, so it's likely not real either, rather a metaphor for . confronting her mental issues in the form of Bloodshot D.